- Take samples from 24 bubble free cells at up to 20 sampling time points
- Open air system, no pressure build up during the tests, no leakage
- Syringe pump sampling system accuracy to ± 1 %
- Sampling takes place before media replacement to avoid sample dilution
- Printer for full report
The LOGAN SYSTEM 912-24 is designed to save valuable time by delivering precise transdermal samples into HPLC vials automatically. The membrane is mounted between the cell cap (donor) and the cell body (receptor). The membrane is bathed from below by an isotonic saline solution. Temperature is maintained at 37°C by thermostatically controlled water which enters the lower port of the water jacket surrounding the saline solution chamber and circulates out through the upper port. Water is supplied and removed by two (upper and lower) stainless steel manifolds connected to a constant temperature bath.
Homogenous distribution of temperature in the saline bathing solution is accomplished by the agitating motion of a Teflon-covered magnetic stirring bar, driven by an external magnet mounted on a timing motor. The cell cap is open to the air, exposing the membrane’s upper surface to ambient conditions. The open cap also allows for a finite dosage application of the compound being studied.
The SYP Series Syringe Pump Module withdraws and measures sample volumes from transdermal diffusion cells at each time interval. Individual samples are dispensed simultaneously into HPLC vials that are stored in the SCT Series Sample Collectors. To avoid sample dilution, the replacement of media takes place right after each sampling. The lift plate tilts all Franz cells to allow any air bubbles to purge out of the cells while doing the media replacement. This will insure that there will be no air bubbles under the skin/patch; the tilted plate goes back to the horizontal position once the media replacement is complete and continues the test.